The "Sydney Sweeney Confused" meme originates from an interview clip featuring actress Sydney Sweeney, known for her role in "Euphoria." The meme typically uses a two-panel format: the top panel shows someone (often the interviewer, or another person in the conversation) with a smiling or enthusiastic expression, while the bottom panel features Sydney Sweeney looking distinctly confused, skeptical, or unimpressed. This meme is used to express a reaction of bewilderment or disbelief in response to a statement, idea, or explanation from another person that is either nonsensical, overly simplistic, or clearly incorrect, despite the presenter's positive demeanor. It highlights a disconnect in understanding or a subtle "side-eye" of judgment.