The 'Peter Griffin Running Away From A Plane' meme originates from a scene in the popular animated sitcom "Family Guy," specifically from the Season 5 episode "Barely Legal." In this scene, Peter Griffin is comically and desperately fleeing a crop duster plane that is spraying him with chemicals. The meme is widely used to humorously depict situations where one is trying to escape or avoid an undesirable, annoying, or overwhelming person, task, or situation. It conveys a strong sense of urgency, panic, or even exasperated avoidance, often resonating with relatable feelings of wanting to "nope out" of an uncomfortable or inconvenient scenario. Its versatility makes it a popular choice for expressing flight from various real-life or internet-related pressures.